蔡成云
发布时间:2020-05-14   浏览次数:29

蔡成云 博士,生命科学学院讲师

caichengyun86@163.com


       毕业于南京医科大学药学院药理学专业,主要从事情感障碍类疾病的研究,在焦虑症、抑郁症、恐惧记忆等的分子及神经环路研究中具有丰富的经验,熟悉神经环路研究相关技术手段。在 J Neurosci、Behav Brain Res、Biochem Biophys Res Commun等期刊上发表研究论文 7 篇,累计影响因子 25.825 分,其中一作及共同一作 4 篇。


现主要研究方向:

1.生理和病理状态血管新生的遗传调控;

2.耳聋发生的分子遗传机制研究;

3.小脑发育过程中分子及环路机制研究;

4.焦虑症和恐惧记忆的分子及神经环路机制。


近三年发表的主要论文如下:

1.Cai CY, Chen C, Zhou Y, Han Z, Qin C, Cao B, Tao Y, Bian XL, Lin YH, Chang L, Wu HY, Luo CX, Zhu DY. PSD-95-nNOS coupling regulates contextual fear extinction in the dorsal CA3. Sci Rep. (2018) 8: 12775. (IF: 4.122)

2.Cai CY, Wu HY, Luo CX, Zhu DY, Zhang Y, Zhou QG, Zhang J. Extracellular regulated protein kinaseis critical for the role of 5-HT1a receptor in modulating nNOS expression and anxiety-related behaviors. Behav Brain Res. (2017) 8897.(IF: 3.173)

3.1Bian XL, 1Qin C, 1Cai CY, Zhou Y, Tao Y, Han Z, Lin YH, Wu HY, Chang L, Luo CX, Zhu DY. Anterior cingulate cortex-ventral hippocampus circuit mediates contextual fear generalization. J.Neurosci. (2019) 39: 5728-5739. (IF: 6.074)

4. 1Qin C, 1Bian XL, 1Cai CY, Chen C, Zhou Y, Lin YH, Tao Y, Han Z, Wu HY, Chang L, Luo CX, Zhu DY. Uncoupling nNOS-PSD-95 can inhibit contextual fear generalization over time. Biochem Biophys Res Commun. (2019) 513: 248-254. (IF: 2.705)

5.Zhang J, Cai CY, Wu HY, Zhu LJ, Luo CX, Zhu DY. CREB-mediated synaptogenesis and neurogenesis is crucial for the role of 5-HT1a receptors in modulating anxiety behaviors. Sci Rep. (2016) 6:29551.(IF: 4.633)

6.Li J, Han Z, Cao B, Cai CY, Lin YH, Li F, Wu HY, Chang L, Luo CX, Zhu DY. Disrupting nNOS-PSD-95 coupling in the hippocampal dentate gyrus promotes extinction memory retrieval. Biochem Biophys Res Commun. (2017) 493(1):862-868.(IF: 2.559)

7.Cao B, Ni HY, Li J, Zhou Y, Bian XL, Tao Y, Cai CY,Wu HY, Chang L, Luo CX, Zhu DY. (+)-Borneol suppresses conditioned fear recall and anxiety-like behaviors in mice.       Biochem Biophys Res Commun. (2018) 495(2):1588-1593. (      IF: 2.559)