沈玉倩
发布时间:2021-09-03   浏览次数:744

沈玉倩 博士,讲师

   

        2013于南通大学获得本科学位;2021于东南大学获得生物学博士学位。

       

   主要研究方向:

(1)神经退行性疾病的潜在分子机制解析

(2)膜蛋白跨膜运动的分子机制解析


   参与多项国家自然科学基金项目研究:

(1)国家自然科学基金项目PQBP1基因突变导致智力障碍的机制研究,2018-012022-12在研,参与

(2)国家自然科学基金项目:智力障碍相关蛋白PQBP1通过调控eEF2磷酸化介导蛋白质翻译的机制研究,2017-012020-12已结题,参与



近五年发表的论文:

(1)Cheng S(#), Shen Y, Zhang ZC(*), Han J(*). Protocol for interfering peptide injection into adult mouse hippocampus and spatial memory testing. STAR Protoc. 2021 Jul 17;2(3):100679. doi: 10.1016/j.xpro.2021.100679. PMID: 34337444; PMCID: PMC8313749.

(2)Shen Y(#), Liu W(#), Zuo J, Han J(*), Zhang ZC(*). Protocol for visualizing newly synthesized proteins in primary mouse hepatocytes. STAR Protoc. 2021 Jun 17;2(3):100616. doi: 10.1016/j.xpro.2021.100616. PMID: 34189479; PMCID: PMC8220402.

(3)Shen Y(#), Zhang ZC(#)(*), Cheng S(#), Liu A, Zuo J, Xia S, Liu X, Liu W, Jia Z, Xie W, Han J(*). PQBP1 promotes translational elongation and regulates hippocampal mGluR-LTD by suppressing eEF2 phosphorylation. Mol Cell. 2021 Apr 1;81(7):1425-1438.e10. doi: 10.1016/j.molcel.2021.01.032. Epub 2021 Mar 3. PMID: 33662272.

(4)Shen Y(#), Han J(*), Zhang ZC(*). Novel regulation of the eEF2K/eEF2 pathway: prospects of 'PQBP1 promotes translational elongation and regulates hippocampal mGluR-LTD by suppressing eEF2 phosphorylation'. J Mol Cell Biol. 2021 Mar 18;13(5):392–4. doi: 10.1093/jmcb/mjab017. Epub ahead of print. PMID: 33734395; PMCID: PMC8373267.

(5)Zhang XY(#), Qi J, Shen Y, Liu X, Liu A, Zhou Z, Han J(*), Zhang ZC(*). Mutations of PQBP1 in Renpenning syndrome promote ubiquitin-mediated degradation of FMRP and cause synaptic dysfunction. Hum Mol Genet. 2017 Mar 1;26(5):955-968. doi: 10.1093/hmg/ddx010. PMID: 28073926.