科研团队：仿生材料与组织工程研究团队
团队网站：https://www.x-mol.com/groups/BMTEers
一、团队研究方向：
南通大学“仿生材料与组织工程研究”团队的主要研究方向为：1. 临床生物医用材料与体外诊断试剂的研发；2. 功能复合材料；3. 仿生材料与组织工程；4. 药物可控缓释系统。团队围绕材料学、细胞与分子生物学、临床医学等多学科交叉，以仿生生物医用材料为工具重点探索支架与（干）细胞/组织相互作用机制、疾病诊断、药物可控释放系统、再生医学方面的基础和应用研究。
二、团队负责人简介
袁卉华博士, 教授, 硕士生导师。江苏省“六大人才高峰”高层次人才培养对象。现任SCI期刊 Frontiers in Bioengineering and Biotechnology（IF2024=4.7）副主编（Associate Editor 生物材料类），中国技术市场协会医疗器械科技创新专业委员会专家委员，国家自然科学基金通讯评审专家，全国研究生教育评估监测专家库专家，全国本科毕业论文（设计）抽检评审专家库专家，江苏省高新技术企业认定评审专家，广东省科技咨询专家。在生物材料、纳米技术、高分子复合材料等领域的学术刊物上发表论文50余篇，撰写英文专著的1个章节，获授权20项中国发明专利。迄今SCI 论文被引用2000次以上， H-指数=25（https://www.researchgate.net/profile/Huihua-Yuan）。其中有1篇论文荣获2023年第三季度Wiley中国开放科学高贡献作者奖1篇，1篇论文得到Biomed. Mater.国际学术期刊编辑的重点推荐（Editor’s Pick），被选为特色文章（Featured articles），并在期刊网站进行采访报道。为中国化学会高级会员，中国生物材料学会、中国生物医学工程学会以及国际组织工程与再生医学会员，也是Adv. Funct. Mater., Adv. Sci., ACS Nano, Small等国际TOP学术期刊的受邀论文评审人。近年来，承担国家、江苏省、南通市科技计划项目等10余项课题。
三、团队成员
教师
宣红云博士、副教授
李碧云博士、高级实验师
金艳博士、讲师
薛也博士、讲师
研究生
陈瑶、蒋伟、顾浩楠、卢科宇、刘子豪、苟亚婷、袁雨桐、唐志旋
四、科研项目
2025-2027：国家自然科学基金-青年项目：神经性疾病调控机制（金艳）
2019-2021: 国家自然科学基金-青年项目：肌腱再生（袁卉华）
2021-2023: 国家自然科学基金-青年项目：神经再生（宣红云）
2020-2023: 江苏省自然科学基金-青年基金项目：神经再生（宣红云）
2018-2021: 江苏省自然科学基金-青年基金项目：肌腱再生（袁卉华）
2018-2020: 江苏省“六大人才高峰”高层次人才项目：肌腱再生（袁卉华）
2020-2023: 江苏省高校自然科学研究面上项目：神经再生（宣红云）
2022-2024：南通市科技项目：骨再生（袁卉华）
2021-2023: 南通市科技项目：神经再生（薛也）
2021-2023: 南通市科技项目：神经性疾病调控机制（金艳）
2019-2021: 南通市科技项目：气管软骨再生（李碧云）
2019-2021: 南通市科技项目：神经再生（宣红云）
2017-2019: 南通市科技项目：肌腱再生（袁卉华）
五、近5年主要论文及著作
1.Shuo Wei, Feng Xiong, Haonan Gu, Zhuojun Zhang, Hongyun Xuan, Yan Jin, Ye Xue, Biyun Li*, Wei Feng*, Huihua Yuan*. Highly aligned electroactive ultrafine fibers promote the differentiation of mesenchymal stem cells into Schwann-like cells for nerve regeneration. International Journal of Biological Macromolecules, 2024, 279:135388.
2.Zhuojun Zhang, Nianci Li, Li Sun, Zihao Liu, Yan Jin, Ye Xue, Biyun Li, Hongyun Xuan*, Huihua Yuan*. Eggshell membrane powder reinforces adhesive polysaccharide hydrogels for wound repair. International Journal of Biological Macromolecules, 2024, 269:131879.
3.Shuo Wei, Yating Gou, Zepeng Huang, Miao Sun, Yan Jin, Ye Xue, Biyun Li*, Hongyun Xuan*, Huihua Yuan*. Solvatochromic, solvent-assisted deformable, and self-reinforcing smart windows enabled by molecular reconfiguration. Polymer, 2024, 296:126794.
4.Hongyun Xuan#, Shuyuan Wu#, Yan Jin#, Shuo Wei, Feng Xiong, Ye Xue, Biyun Li*, Yumin Yang*, Huihua Yuan*. A bioinspired self-healing conductive hydrogel promoting peripheral nerve regeneration. Advanced Science, 2023, 10(28): 2302519.
5.Feng Xiong#, Shuo Wei#, Shuyuan Wu, Wei Jiang, Biyun Li, Hongyun Xuan, Ye Xue*, Huihua Yuan*. Aligned electroactive electrospun fibrous scaffolds for peripheral nerve regeneration. ACS Appl. Mater. Interfaces, 2023, 15, 41385−41402.
6.Hongyun Xuan#, Zhuojun Zhang#, Wei Jiang, Nianci Li, Li Sun, Ye Xue*, Haitao Guan*, Huihua Yuan*. Dual-bioactive molecules loaded aligned core-shell microfibers for tendon tissue engineering. Colloids and surfaces B: Biointerfaces, 2023, 228:113416.
7.Hongyun Xuan#, Qian Du#, Ruimeng Li, Xiaoni Shen, Jiao Zhou, Biyun Li, Yan Jin*, Huihua Yuan*. Shape-Memory-Reduced Graphene/Chitosan Cryogels for Non-Compressible Wounds. International Journal of Molecular Sciences, 2023, 24, 1389.
8.Biyun Li, Xiaoxiao Gao,Jiangang Qu, Feng Xiong, Hongyun Xuan, Yan Jin*, Huihua Yuan*. Visible-light-driven antimicrobial activity and mechanism of polydopamine-reduced graphene oxide/BiVO4 Composite. International Journal of Molecular Sciences, 2022, 23(14):7712.
9.Shuyuan Wu, Zhuojun Zhang, Ran Xu, Shuo Wei, Feng Xiong, Wenzhuo Cui, Biyun Li,Ye Xue*, Hongyun Xuan*, Huihua Yuan*. A spray-filming, tissue-adhesive, and bioactive polysaccharide self-healing hydrogel for skin regeneration. Materials & Design, 2022, 217:110669.
10.Feng Xiong, Shuo Wei, Han Sheng, Xiang Han, Wei Jiang, Zhuojun Zhang, Biyun Li, Hongyun Xuan, Ye Xue*, Huihua Yuan*. In situ polydopamine functionalized poly-L-lactic acid nanofibers with near-infrared-triggered antibacterial and reactive oxygen species scavenging capability. International Journal of Biological Macromolecules, 2022, 201:338-350.
11.Xiaolei Li#, Feng Xiong#, Shuguang Wang, Zhuojun Zhang, Jihang Dai, Hui Chen, Jingcheng Wang, Qiang Wang*, Huihua Yuan*. N-acetyl-cysteine-loaded biomimetic nanofibrous scaffold for osteogenesis of induced-pluripotent-stem-cell-derived mesenchymal stem cells and bone regeneration. Frontiers in Bioengineering and Biotechnology, 2021, 9:767641.
12.Hongyun Xuan#, Shuo Wei#, Feng Xiong, Zhuojun Zhang, Ye Xue, Miao Sun*, Biyun Li*, Huihua Yuan*. Design of porous and fish scale-like nanofibers for the reinforcement of transparent composites. Materials & Design, 2021, 212:110284.
13.Cong Gao, Shuai Lu, Yongzhou Wang, Hao Xu, Xiaoxiao Gao, Yiwen Gu, Hongyun Xuan, Baohua Wang*, Huihua Yuan*, Yunying Cao*. Bismuth vanadium oxide can promote growth and activity in Arabidopsis thaliana. Frontiers in Chemistry, 2021, 9:766078.
14.Hongyun Xuan, Shuyuan Wu, Simiao Fei, Biyun Li, Yumin Yang*, Huihua Yuan*. Injectable nanofiber-polysaccharide self-healing hydrogels for wound healing. Materials Science & Engineering C, 2021, 128: 112264.
15.Biyun Li, Shuo Wei, Hongyun Xuan, Ye Xue, Huihua Yuan*. Tailoring fineness and content of nylon-6 nanofibers for reinforcing optically transparent poly(methyl methacrylate) composites. Polymer Composites, 2021, 1-10.
16.Hongyun Xuan#, Biyun Li#, Feng Xiong, Shuyuan Wu, Zhuojun Zhang, Yumin Yang*, Huihua Yuan*. Tailoring nano-porous surface of aligned electrospun poly(L-lactic acid) fibers for nerve tissue engineering. International Journal of Molecular Science, 2021, 22:3536.
17.Huihua Yuan#,*, Xiaolei Li#, Ming-Song Lee, Zhuojun Zhang, Biyun Li, Hongyun Xuan, Wan-Ju Li , Yanzhong Zhang*.Collagen and chondroitin sulfate functionalized bioinspired fibers for tendon tissue engineering application. International Journal of Biological Macromolecules, 2021, 170:248-260.
18.Ye Xue, Krista Jackson, Natalie Page, Xiaoyang Mou, Samuel Lofland, Xiao Hu*. Water-annealing regulated protein-based magnetic nanofiber materials: tuning silk structure and properties to enhance cell response under magnetic fields, Materials Today Chemistry, 2021, 22: 100570.
19.Biyun Li#, Yinhu Liu#, Shuo Wei, Yuting Huang, Shuwen Yang, Ye Xue, Hongyun Xuan, Huihua Yuan*. A solvent system involved fabricating electrospun polyurethane nanofibers for biomedical applications. Polymers, 2020, 12:3038.
20.Biyun Li#, Feng Xiong#, Bo Yao, Qian Du, Jun Cao, Jiangang Qu, Wei Feng*, Huihua Yuan*. Preparation and characterization of antibacterial dopamine-functionalized reduced graphene oxide/PLLA composite nanofibers. RSC Advances, 2020,10:18614-18623.
21.Hongyun Xuan, Xiaoxuan Tang, Yanxi Zhu, Jue Ling*, Yumin Yang*. Freestanding hyaluronic acid/silk-based self-healing coating towards tissue repair with antibacterial surface. ACS Applied Bio-materials, 2020,3(3):1628-1635.
22.Ye Xue, Sam Lofland, Xiao Hu*. Protein-based flexible thermal conductive materials with continuous network structure: fabrication, properties, and theoretical modeling, Composites Part B Engineering, 2020, 201(49): 108377.
23.Ye Xue, Sam Lofland, Xiao Hu*. Comparative study of silk-based magnetic materials: effect of magnetic particle types on the protein structure and biomaterial properties, International Journal of Molecular Sciences, 2020, 21(20): 7583.
24.Ye Xue, Xiao Hu*. Electrospun silk-boron nitride nanofibers with tunable structure and properties, Polymers, 2020, 12(5): 1093.
#表示共同一作，*通讯作者
六：指导学生获奖情况
1.指导2023级硕士研究生获首届“技创杯”医疗器械技术创新与应用技能大赛二等奖1项。
2.指导2022级本科生活国家级大创项目1项。
3.指导2020、2021级硕士研究生获江苏省研究生创新基金项目资助2项。
4.指导2020级硕士研究生获2021年江苏省化工新材料研究生学术创论坛优秀墙报奖1项。
5.指导2017级生物技术、生物工程本科生完成国家级大创项目1项。
6.指导2018级海洋技术本科生获2022全国生命科学竞赛江苏赛区三等奖一项。
7.指导2020届、2021届生物科学、生物工程本科生获江苏省普通高校本专科优秀毕业设计（论文）三等奖2项。
七、联系方式以及其它信息
Email: yuanhh@ntu.edu.cn
欢迎感兴趣的青年人才和同学加入！