科研团队：神经损伤修复与再生
一、团队简介：围绕神经损伤后的修复、再生与功能重建等当今神经科学和再生医学领域的前沿课题，开展系统和深入的基础和应用研究。主要研究方向：1.周围神经损伤修复与再生过程中内在生长能力激活和调控机制；2. Wallerian溃变在周围神经损伤修复与再生过程中的分子机制；3. 缺血缺氧损伤后神经保护和功能重建的作用机制；4. 新材料在神经损伤修复与再生过程的应用及作用机理。
二、团队负责人简介：
姚登兵，博士，教授，博导。中国解剖学会再生医学分会委员、中国研究型医院学会神经再生与修复专业委员会委员、江苏省生物学科联盟副理事长、江苏省生物技术协会副理事长、江苏省发育生物学会理事、《交通医学》杂志副主编。主讲神经生物学、分子生物学、基因工程和酶工程等课程。研究方向：周围神经损伤修复与再生。主持国家自然科学基金面上项目、教育部留学回国人员科研基金、江苏省自然科学基金面上项目、江苏省高校自然科学基金面上项目、南通市应用基础研究计划项目等课题。荣获南通市第五届青年科技奖、南通市第四届杰出专业技术人才、江苏省科学技术三等奖、江苏省生物技术协会科技创新一等奖、江苏省高校科技进步二等奖、江苏省医学新技术引进二等奖、南通市科技进步二、三等奖，南通大学教学成果二等奖等。
三、团队成员：
1. 蒋茂荣，博士，副教授，硕士生导师
2. 白慧媛，博士，讲师
研究生：
冯宇枚
丁梓晗
钱嘉锡
周宜月
顾丹丹
四、研究课题：
2020-2023: 国家自然科学基金-面上项目（姚登兵）
2020-2021: 国家自然科学基金-国际合作项目（姚登兵）
2014-2017: 国家自然科学基金-面上项目（姚登兵）
2012-2014：国家自然科学基金-青年项目（蒋茂荣）
2015-2018：江苏省自然科学基金-面上项目（蒋茂荣）
五、主要论文：
1. Yumei Feng, Jian Shao, Min Cai Yiyue Zhou, Yi Yao, Jiaxi Qian, Zihan Ding, Maorong Jiang, Dengbing Yao. Long noncoding RNA H19 regulates degeneration and regeneration of injured peripheral nerves. Neural Regen Res. 2023, 18(8):1847-1851.
2. Min Cai, Jian Shao, Bryant Yung, Yi Wang, Nannan Gao, Xi Xu, Huanhuan Zhang, Yumei Feng, Dengbing Yao. Baculoviral inhibitor of apoptosis protein repeat-containing protein 3 delays early Wallerian degeneration after sciatic nerve injury. Neural Regen Res. 2022, 17(4):845-853.
3. Yuting Li, Min Cai, Yumei Feng, Bryant Yung, Yi Wang, Nannan Gao, Xi Xu, Huanhuan Zhang, Huiwei Huang, Dengbing Yao. Effect of lncRNA H19 on nerve degeneration and regeneration after sciatic nerve injury in rats. Dev Neurobiol. 2022, 82(1):98-111.
4. Lei Qian, Ming Li, Xin Lin, Hongwei Teng, Lulu Yu, Maorong Jiang. Interleukin-35 attenuates blood-brain barrier dysfunction caused by cerebral ischemia-reperfusion injury through inhibiting brain endothelial cell injury. Ann Transl Med. 2022, 10(14):776.
5. Huiyuan Bai, Zhibin Huang, Lei Zhang. Ultrathin scroll-like CdSe/CdS core/crown heteronanoplatelets: Colloidal synthesis and properties. Colloid Surface A. 2022, 648: 1-7.
6. Min Cai, Jian Shao, Yi Wang, Bryant Yung, Jiannan Li, Huanhuan Zhang, Yuting Li, Dengbing Yao. Claudin 14/15 play important roles in early wallerian degeneration after rat sciatic nerve injury. Chin J Traumatol. 2021, 24(6):374-382.
7. Yi Wang, Nannan Gao, Yumei Feng, Min Cai, Yuting Li, Xi Xu, Huanhuan Zhang, Dengbing Yao. Protein kinase C theta (Prkcq) affects nerve degeneration and regeneration through the c-fos and c-jun pathways in injured rat sciatic nerves. Exp Neurol. 2021, 346:113843.
8. Jiaqi Li, Maorong Jiang, JiaoRui Zhou, Junjie Ding, Zhimou Guo, Ming Li, Fei Ding, Wengang Chai, Jingyu Yan, Xinmiao Liang. Characterization of rat and mouse acidic milk oligosaccharides based on hydrophilic interaction chromatography coupled with electrospray tandem mass spectrometry. Carbohydr Polym. 2021, 259:117734.
9. Huiyuan Bai, Quanhao Sun, Fei Kong, Haijiao Dong, Ming Ma, Fangzhou Liu, Chen Wang, Haiyan Xu, Ning Gu, Yu Zhang. Zwitterion-functionalized hollow mesoporous Prussian blue nanoparticles for targeted and synergetic chemo-photothermal treatment of acute myeloid leukemia. J Mater Chem B. 2021, 9(26):5245-5254.
10. Huiyuan Bai, Tao Wang, Fei Kong, Meichen Zhang, Zhuoxuan Li, Linlin Zhuang, Ming Ma, Fangzhou Liu, Chen Wang, Haiyan Xu, Ning Gu, YuZhang. CXCR4 and CD44 dual-targeted Prussian blue nanosystem with daunorubicin loaded for acute myeloid leukemia therapy. Chem Eng J. 2021, 45: 1-13.
11. Maorong Jiang, Ran Li, Jingjun Lyu, Xuan Li, Wei Wang, Zhuoran Wang, Huaxin Sheng, Weiguo Zhang, Jörn Karhausen, Wei Yang. MCC950, a selective NLRP3 inflammasome inhibitor, improves neurologic function and survival after cardiac arrest and resuscitation. J Neuroinflammation. 2020, 31;17(1):256.
12. Maorong Jiang, Hui Shi, Yunzhao Xu, Wen Bai, Peiwen Wang, Qianqian Ju. miR-203a-3p regulates the cellular processes of esophageal cancer cells via targeting CtBP2. Transl Cancer Res. 2019, 8(8):2791-2802.
13. Huanhuan Zhang, Zhiwei Shao, Yun Zhu, Lingyu Shi, Zhihao Li, Rui Hou, Chunwang Zhang, Dengbing Yao. Toll-Like Receptor 4 (TLR4) Expression Affects Schwann Cell Behavior in vitro. Sci Rep. 2018, 25;8(1):11179.
14. Yuting Li, Yuhua Sun, Min Cai, Huanhuan Zhang, Nannan Gao, Huiwei Huang, Shusen Cui, Dengbing Yao. Fas Ligand Gene (Faslg) Plays an Important Role in Nerve Degeneration and Regeneration After Rat Sciatic Nerve Injury. Front Mol Neurosci. 2018, 19;11:210.
15. Yingcheng Wu, Qianqian Ju, Keren Jia, Jingyan Yu, Hui Shi, Huiqun Wu, Maorong Jiang. Correlation between sex and efficacy of immune checkpoint inhibitors (PD-1 and CTLA-4 inhibitors). Int J Cancer. 2018, 143(1):45-51.
16. Hui Shi, Yinting Mao, Qianqian Ju, Yingcheng Wu, Wen Bai, Peiwen Wang, Yudong Zhang, Maorong Jiang. C-terminal binding protein‑2 mediates cisplatin chemoresistance in esophageal cancer cells via the inhibition of apoptosis. Int J Oncol. 2018, 53(1):167-176.
17. Hui Shi, Feng Yu, Yinting Mao, Qianqian Ju, Yingcheng Wu, Wen Bai, Peiwen Wang, Ran Xu, Maorong Jiang, Jiahai Shi. EphA2 chimeric antigen receptor-modified T cells for the immunotherapy of esophageal squamous cell carcinoma. J Thorac Dis. 2018, 10(5):2779-2788.
18. Hui Shi, Jiahai Shi, Yudong Zhang, Chengqi Guan, Jun Zhu, Fei Wang, Mingming Xu, Qianqian Ju, Shu Fang, Maorong Jiang. Long non-coding RNA DANCR promotes cell proliferation, migration, invasion and resistance to apoptosis in esophageal cancer. J Thorac Dis. 2018, 10(5):2573-2582.
19. Xingyu Liu, Yuhua Sun, Huaiqin Li, Yuting Li, Meiyuan Li, Ying Yuan, Shusen Cui, Dengbing Yao. Effect of Spp1 on nerve degeneration and regeneration after rat sciatic nerve injury. BMC Neurosci. 2017, 7;18(1):30.
20. Min Yao, Min Cai, Dengfu Yao, Xi Xu, Rongrong Yang, Yuting Li, Yuanyuan Zhang, Hiroshi Kido, Dengbing Yao. Abbreviated half-lives and impaired fuel utilization in carnitine palmitoyltransferase II variant fibroblasts. PLoS One. 2015, 17;10(3):e0119936.
21. Meiyuan Li, Pingan Zhang, Huaiqin Li, Yun Zhu, Shusen Cui, Dengbing Yao. TGF-β1 is critical for Wallerian degeneration after rat sciatic nerve injury. Neuroscience. 2015, 22;284:759-767.
22. Meiyuan Li, Pingan Zhang, Weimin Guo, Huaiqin Li, Xiaosong Gu, Dengbing Yao. Protein expression profiling during wallerian degeneration after rat sciatic nerve injury. Muscle Nerve. 2014, 50(1):73-8.
23. Leilei Gong, Yun Zhu, Xi Xu, Huaiqin Li, Weimin Guo, Qin Zhao, Dengbing Yao. The effects of claudin 14 during early Wallerian degeneration after sciatic nerve injury. Neural Regen Res. 2014, 15;9(24):2151-8.
24. Nan Jiang, Huaiqin Li, Yi Sun, Dexin Yin, Qin Zhao, Shusen Cui, Dengbing Yao. Differential gene expression in proximal and distal nerve segments of rats with sciatic nerve injury during Wallerian degeneration. Neural Regen Res. 2014, 15;9(12):1186-94.
25. Maorong Jiang, Qiong Cheng, Wenfeng Su, Caiping Wang, Yuming Yang, Zheng Cao, Fei Ding. The beneficial effect of chitooligosaccharides on cell behavior and function of primary Schwann cells is accompanied by up-regulation of adhesion proteins and neurotrophins. Neurochem Res. 2014, 39(11):2047-57.
26. Maorong Jiang, Zhimou Guo, Caiping Wang, Yuming Yang, Xinmiao Liang, Fei Ding. Neural activity analysis of pure chito-oligomer components separated from a mixture of chitooligosaccharides. Neurosci Lett. 2014, 581:32-6.
27. Dengbing Yao, Meiyuan Li, Dingding Shen, Fei Ding, Shibi Lu, Qing Zhao, Xiaosong Gu. Expression changes and bioinformatic analysis of Wallerian degeneration after sciatic nerve injury in rat. Neurosci Bull. 2013, 29(3):321-32.
28. Meiyuan Li, Weimin Guo, Pingan Zhang, Huaiqin Li, Xiaosong Gu, Dengbing Yao. Signal flow and pathways in response to early Wallerian degeneration after rat sciatic nerve injury. Neurosci Lett. 2013, 536:56-63.