微生物与遗传学

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王凯

日期:2023-08-02   点击数:885  


姓名:王凯    职称:教授,博士生导师

个人简介

教育部新世纪优秀人才。先后获“闽江学者”特聘教授、“金山学者”特聘教授,福建省引进高层次人才等称号。曾任国家甘蔗工程技术研究中副主任、副院长等职务。现已在Science, Nature Genetics, Genome ResPlant Cell等期刊发表论文近90篇,参编英文著作1部,申请发明专利十余项。现任SCI杂志Frontiers in Plant ScienceChromosome Res编委,美国自然科学基金评委;担任国际棉花基因组创新研讨会会员,中国热带作物学会理事,福建省遗传学会理事。

性别/籍贯/学历学位等信息

专业研究领域

1. 植物(作物)重要性状决定基因的挖掘与分子遗传调控机制解析;

2. 植物基因组结构与演化。

 

专著与论集

1.        Saleem Ur Rahman, Hamza Ramzan, Haris Khurshid, Niaz Ahmad, Kai Wang, Zahid Mukhtar, G. Raza, Role of Biotechnology for Improvement of Sugarcane, in: R.K. Gaur (Ed.), Omics Approaches for Sugarcane Crop Improvement, CRC Press, Boca Raton, 2022.

2.        Li Z, Wang K (2019) Genome-Wide Identification of Regulatory DNA Elements in Crop Plants. In: Vaschetto LM (ed) Cereal Genomics: Methods and Protocols. Springer US, New York, NY, pp 85-99

3.         

 

学术论文

4.        J. Han, D. Lopez-Arredondo, G. Yu, Y. Wang, B. Wang, S.B. Wall, X. Zhang, H. Fang, A.C. Barragan-Rosillo, X. Pan, Y. Jiang, J. Chen, H. Zhang, B.L. Zhou, L. Herrera-Estrella, B. Zhang, K. Wang, Genome-wide chromatin accessibility analysis unveils open chromatin convergent evolution during polyploidization in cotton, Proc. Natl. Acad. Sci. U. S. A. 119(44) (2022) e2209743119.

5.        X. Zhang, Z. Meng, J. Han, H. Khurshid, A. Esh, R. Hasterok, K. Wang, Characterization of meiotic chromosome behavior in the autopolyploid Saccharum spontaneum reveals preferential chromosome pairing without distinct DNA sequence variation, The Crop Journal (2023).

6.        W. Ding, Y. Zhu, J. Han, H. Zhang, Z. Xu, H. Khurshid, F. Liu, R. Hasterok, X. Shen, K. Wang, Characterization of centromeric DNA of Gossypium anomalum reveals sequence-independent enrichment dynamics of centromeric repeats, Chromosome Res. 31(2) (2023) 12.

7.        K. Wang, H. Zhang, H. Khurshid, A. Esh, C. Wu, Q. Wang, N. Piperidis, Past and recent advances in sugarcane cytogenetics, The Crop Journal 11(1) (2023) 1-8.

8.        Xu Z, Chen J, Meng S, Xu P, Zhai C, Huang F, Guo Q, Zhao L, Quan Y, Shangguan Y, Meng Z, Wen T, Zhang Y, Zhang X, Zhao J, Xu J, Liu J, Gao J, Ni W, Chen X, Ji W, Wang N, Lu X, Wang S, Wang K, Zhang T, Shen X (2022) Genome sequence of Gossypium anomalum facilitates interspecific introgression breeding. Plant Communications:100350

9.        R. Hasterok, P. Catalan, S.P. Hazen, A.C. Roulin, J.P. Vogel, K. Wang, L.A.J. Mur, Brachypodium: 20 years as a grass biology model system; the way forward?, Trends Plant Sci. 27(10) (2022) 1002-1016.

10.    Huang Y, Ding W, Zhang M, Han J, Jing Y, Yao W, Hasterok R, Wang Z, Wang K (2021) The formation and evolution of centromeric satellite repeats in Saccharum species. Plant J 106:616-629

11.    Wang Q, Yu G, Chen Z, Han J, Hu Y, Wang K (2021) Optimization of protoplast isolation, transformation and its application in sugarcane (Saccharum spontaneum L). The Crop Journal , 9:133-142

12.    Han J, Wang P, Wang Q, Lin Q, Chen Z, Yu G, Miao C, Dao Y, Wu R, Schnable JC, Tang H, Wang K (2020) Genome-wide characterization of DNase I-hypersensitive sites and cold response regulatory landscapes in grasses. Plant Cell 32:2457-2473

13.    Lin Q, Wang S, Dao Y, Wang J, Wang K (2020) The Arabidopsis thaliana trehalose-6-phosphate phosphatase gene AtTPPI enhances drought tolerance by regulating stomatal apertures. J Exp Bot 71:4285-4297

14.    Zhang L, Chen F, Zhang X, Li Z, Zhao Y, Lohaus R, Chang X, Dong W, Ho SYW, Liu X, Song A, Chen J, Guo W, Wang Z, Zhuang Y, Wang H, Chen X, Hu J, Liu Y, Qin Y, Wang K, Dong S, Liu Y, Zhang S, Yu X, Wu Q, Wang L, Yan X, Jiao Y, Kong H, Zhou X, Yu C, Chen Y, Li F, Wang J, Chen W, Chen X, Jia Q, Zhang C, Jiang Y, Zhang W, Liu G, Fu J, Chen F, Ma H, Van de Peer Y, Tang H (2020) The water lily genome and the early evolution of flowering plants. Nature 577:79-84

15.    Meng Z, Han J, Lin Y, Zhao Y, Lin Q, Ma X, Wang J, Zhang M, Zhang L, Yang Q, Wang K (2020) Characterization of a Saccharum spontaneum with a basic chromosome number of x = 10 provides new insights on genome evolution in genus Saccharum. Theor Appl Genet 133:187-199

16.    Huang Y, Chen H, Han J, Zhang Y, Ma S, Yu G, Wang Z, Wang K (2020) Species-specific abundant retrotransposons elucidate the genomic composition of modern sugarcane cultivars. Chromosoma 129:45-55

17.    Hasterok R, Wang K, Jenkins G (2020) Progressive refinement of the karyotyping of Brachypodium genomes. New Phytol, DOI 10.1111/nph.16342

18.    Lin Q, Yang J, Wang Q, Zhu H, Chen Z, Dao Y, Wang K (2019) Overexpression of the trehalose-6-phosphate phosphatase family gene AtTPPF improves the drought tolerance of Arabidopsis thaliana. BMC Plant Biol 19:381

19.    Wang S, Jin W, Wang K (2019) Centromere histone H3- and phospholipase-mediated haploid induction in plants. Plant Methods 15:42

20.    Hu Y, Chen J, Fang L, Zhang Z, Ma W, Niu Y, Ju L, Deng J, Zhao T, Lian J, Baruch K, Fang D, Liu X, Ruan YL, Rahman MU, Han J, Wang K, Wang Q, Wu H, Mei G, Zang Y, Han Z, Xu C, Shen W, Yang D, Si Z, Dai F, Zou L, Huang F, Bai Y, Zhang Y, Brodt A, Ben-Hamo H, Zhu X, Zhou B, Guan X, Zhu S, Chen X, Zhang T (2019) Gossypium barbadense and Gossypium hirsutum genomes provide insights into the origin and evolution of allotetraploid cotton. Nat Genet 51:739-748

21.    Li Y, Zuo S, Zhang Z, Li Z, Han J, Chu Z, Hasterok R, Wang K (2018) Centromeric DNA characterization in the model grass Brachypodium distachyon provides insights on the evolution of the genus. Plant J 93:1088-1101

22.    Zhang J, Zhang X, Tang H, Zhang Q, Hua X, Ma X, Zhu F, Jones T, Zhu X, Bowers J, Wai CM, Zheng C, Shi Y, Chen S, Xu X, Yue J, Nelson DR, Huang L, Li Z, Xu H, Zhou D, Wang Y, Hu W, Lin J, Deng Y, Pandey N, Mancini M, Zerpa D, Nguyen JK, Wang L, Yu L, Xin Y, Ge L, Arro J, Han JO, Chakrabarty S, Pushko M, Zhang W, Ma Y, Ma P, Lv M, Chen F, Zheng G, Xu J, Yang Z, Deng F, Chen X, Liao Z, Zhang X, Lin Z, Lin H, Yan H, Kuang Z, Zhong W, Liang P, Wang G, Yuan Y, Shi J, Hou J, Lin J, Jin J, Cao P, Shen Q, Jiang Q, Zhou P, Ma Y, Zhang X, Xu R, Liu J, Zhou Y, Jia H, Ma Q, Qi R, Zhang Z, Fang J, Fang H, Song J, Wang M, Dong G, Wang G, Chen Z, Ma T, Liu H, Dhungana SR, Huss SE, Yang X, Sharma A, Trujillo JH, Martinez MC, Hudson M, Riascos JJ, Schuler M, Chen LQ, Braun DM, Li L, Yu Q, Wang J, Wang K, Schatz MC, Heckerman D, Van Sluys MA, Souza GM, Moore PH, Sankoff D, VanBuren R, Paterson AH, Nagai C, Ming R  (2018) Allele-defined genome of the autopolyploid sugarcane Saccharum spontaneum L. Nat Genet 50:1565-1573

23.    Meng Z, Zhang Z, Yan T, Lin Q, Wang Y, Huang W, Huang Y, Li Z, Yu Q, Wang J, Wang K (2018) Comprehensively characterizing the cytological features of Saccharum spontaneum by the development of a complete set of chromosome-specific oligo probes. Front Plant Sci 9:1624

24.    Han J, Zhang Z, Wang K (2018) 3C and 3C-based techniques: the powerful tools for spatial genome organization deciphering. Mol Cytogenet 11:21

25.    Liu S, Xue C, Fang Y, Chen G, Peng X, Zhou Y, Chen C, Liu G, Gu M, Wang K, Zhang W, Wu Y, Gong Z (2018) Global Involvement of Lysine Crotonylation in Protein Modification and Transcription Regulation in Rice. Mol Cell Proteomics 17:1922-1936

26.    Han J, Masonbrink RE, Shan W, Song F, Zhang J, Yu W, Wang K, Wu Y, Tang H, Wendel JF, Wang K (2016) Rapid proliferation and nucleolar organizer targeting centromeric retrotransposons in cotton. Plant J 88:992-1005

27.    Shan W, Jiang Y, Han J, Wang K (2016) Comprehensive cytological characterization of the Gossypium hirsutum genome based on the development of a set of chromosome cytological markers. The Crop Journal 4:256-265

28.    Han J, Zhou B, Shan W, Yu L, Wu W, Wang K (2015) A and D genomes spatial separation at somatic metaphase in tetraploid cotton: evidence for genomic disposition in a polyploid plant. Plant J 84:1167-1177

29.    Ming R, VanBuren R, Wai CM, Tang H, Schatz MC, Bowers JE, Lyons E, Wang ML, Chen J, Biggers E, Zhang J, Huang L, Zhang L, Miao W, Zhang J, Ye Z, Miao C, Lin Z, Wang H, Zhou H, Yim WC, Priest HD, Zheng C, Woodhouse M, Edger PP, Guyot R, Guo HB, Guo H, Zheng G, Singh R, Sharma A, Min X, Zheng Y, Lee H, Gurtowski J, Sedlazeck FJ, Harkess A, McKain MR, Liao Z, Fang J, Liu J, Zhang X, Zhang Q, Hu W, Qin Y, Wang K, Chen LY, Shirley N, Lin YR, Liu LY, Hernandez AG, Wright CL, Bulone V, Tuskan GA, Heath K, Zee F, Moore PH, Sunkar R, Leebens-Mack JH, Mockler T, Bennetzen JL, Freeling M, Sankoff D, Paterson AH, Zhu X, Yang X, Smith JA, Cushman JC, Paull RE, Yu Q (2015) The pineapple genome and the evolution of CAM photosynthesis. Nat Genet 47:1435-1442

30.    Wang K, Wu Y, Zhang W, Dawe RK, Jiang J (2014) Maize centromeres expand and adopt a uniform size in the genetic background of oat. Genome Res 24:107-116

31.    Zhang H, Koblizkova A, Wang K, Gong Z, Oliveira L, Torres GA, Wu Y, Zhang W, Novak P, Buell CR, Macas J, Jiang J (2014) Boom-Bust Turnovers of Megabase-Sized Centromeric DNA in Solanum Species: Rapid Evolution of DNA Sequences Associated with Centromeres. Plant Cell 26:1436-1447

32.    Cook DE, Bayless AM, Wang K, Guo X, Song Q, Jiang J, Bent AF (2014) Distinct copy number, coding sequence, and locus methylation patterns underlie Rhg1-Mediated soybean resistance to soybean cyst nematode. Plant Physiol 165:630-647

33.    Chen Y, Wang Y, Wang K, Zhu X, Guo W, Zhang T, Zhou B (2014) Construction of a complete set of alien chromosome addition lines from Gossypium australe in Gossypium hirsutum: morphological, cytological, and genotypic characterization. Theor Appl Genet 127:1105-1121

34.     Cook DE, Lee TG, Guo X, Melito S, Wang K, Bayless AM, Wang J, Hughes TJ, Willis DK, Clemente TE, Diers BW, Jiang J, Hudson ME, Bent AF (2012) Copy number variation of multiple genes at Rhg1 mediates nematode resistance in soybean. Science 338:1206-1209

35.    Gong Z, Wu Y, Koblizkova A, Torres GA, Wang K, Iovene M, Neumann P, Zhang W, Novak P, Buell CR, Macas J, Jiang J (2012) Repeatless and repeat-based centromeres in potato: Implications for centromere evolution. Plant Cell 24:3559-3574

36.    Wang K, Zhang W, Cao Y, Zhang Z, Zheng D, Zhou B, Guo W, Zhang T (2012) Localization of high level of sequence conservation and divergence regions in cotton. Theor Appl Genet 124:1173-1182

37.    Zhang H, Phan BH, Wang K, Artelt BJ, Jiang J, Parrott WA, Dawe RK (2012) Stable integration of an engineered megabase repeat array into the maize genome. Plant J 70:357-365

38.    Wang K, Guo W, Yang Z, Hu Y, Zhang W, Zhou B, Stelly D, Chen Z, Zhang T (2010) Structure and size variations between 12A and 12D homoeologous chromosomes based on high-resolution cytogenetic map in allotetraploid cotton. Chromosoma 119:255-266

39.    Wang K, Yang Z, Shu C, Hu J, Lin Q, Zhang W, Guo W, Zhang T (2009) Higher axial-resolution and sensitivity pachytene fluorescence in situ hybridization protocol in tetraploid cotton. Chromosome Res 17:1041-1050

40.    Guan B, Wang K, Zhou BL, Guo WZ, Zhang TZ (2008) Establishment of a multi-color genomic in situ hybridization technique to simultaneously discriminate the three interspecific hybrid genomes in gossypium. J Integr Plant Biol 50:345-351

41.    Wang K, Guo W, Zhang T (2007) Development of one set of chromosome-specific microsatellite-containing BACs and their physical mapping in Gossypium hirsutum L. Theor Appl Genet 115:675-682

42.    Guo W, Cai C, Wang C, Han Z, Song X, Wang K, Niu X, Wang C, Lu K, Shi B, Zhang T (2007) A microsatellite-based, gene-rich linkage map reveals genome structure, function and evolution in Gossypium. Genetics 176:527-541

43.    Wang K, Song X, Han Z, Guo W, Yu JZ, Sun J, Pan J, Kohel RJ, Zhang T (2006) Complete assignment of the chromosomes of Gossypium hirsutum L. by translocation and fluorescence in situ hybridization mapping. Theor Appl Genet 113:73-80

 

主要科研项目 

2021 国家自然科学基金面上项目;

2. 2019 国家重点研发计划子课题;

3. 2018 国家自然科学基金面上项目

4. 2017国家自然科学基金海外学者合作研究基金

5. 2015 国家自然科学基金面上项目

6. 2011 国家自然科学基金面上项目

7. 2011教育部新世纪优秀人才支持计划项目

8. 2008 国家自然科学基金青年科学基金

9. 2008江苏省自然科学基金

10. 2014闽江学者特聘教授

另外,主持云南省博士工作站及其他合作研究课题十余项。

 

讲授课程 

主讲《遗传学》与《生物技术前沿进展》等课程。

指导研究生情况

先后培养博硕士30余人。