学术报告：Molecular control of organo-typical vascular network formation

题　目：Molecular control of organo-typical vascular network formation
主讲人：Ferdinand le Noble
简　历：

报告内容：During evolution, higher vertebrates developed intricately branched vascular networks that perfuse organs according to a form follows function principle. However, the molecular and cellular substrates that add organ specificity to the vascular growth and patterning process are largely unknown. Vascular endothelial growth factor (Vegf) and its receptors are key-regulators of developmental angiogenesis and branching remodeling in most organs including pancreas, liver, skeletal muscle, heart, brain and peripheral nervous system. How this relatively limited set of molecules can account for the great diversity in organ vessel patterning is unknown but considered clinically relevant for designing organo-typical pro- and anti-angiogenic therapies. Through systematic comparison of angiogenic remodeling in a range of tissues, using a series of zebrafish growth factor mutants and transgenics we identified tissue-specific cellular and molecular heterogeneity in the Vegf driven angiogenic remodeling process, to be at the basis of organo-typical formation of vascular networks. Here we will present the specific findings for the developing nervous system.